Lorea Jordana is in the last weeks of the 4-months international stay that she is carrying out since April at the Tissue Engineering group-University of Basel (Switzerland), for the last research stage of her doctoral thesis in Molecular mechanisms governing CAR T cell response in MM patients at Cima-Universidad de Navarra.

And to know how well is she doing, nothing better than her own words:

'During my research stay with the Tissue Engineering group at the University of Basel, I am developing a 3D model of human multiple myeloma (MM) using a perfusion bioreactor system. This innovative model aims to better replicate the tumor microenvironment and will be used to evaluate the effectiveness of CAR T cell therapy—an advanced form of immunotherapy. The project involves:

• Build a bone marrow-like structure.
• Assess how well CAR T cells can eliminate cancer cells within it.
• Study how the CAR T cells function in this complex setting.

Ultimately, this research could help pave the way toward more personalized and effective treatments for MM patients'.

A great experience in an expert group in tissue engineering with challenging applications. Among many others, they mimic complex tissue environments to further the study of key biological processes involved in tissues repair or behaviour against tumors or other diseases. A really innovative and promissing field, combining interdisciplinary approaches across cell biology, engineering technologies and material science.